منابع مشابه
PPAR Ligands for Cancer Chemoprevention
Peroxisome proliferators-activated receptors (PPARs) that are members of the nuclear receptor superfamily have three different isoforms: PPARalpha, PPARdelta, and PPARgamma. PPARs are ligand-activated transcription factors, and they are implicated in tumor progression, differentiation, and apoptosis. Activation of PPAR isoforms lead to both anticarcinogenesis and anti-inflammatory effect. It ha...
متن کاملPPAR ligands: potential therapies for metabolic syndrome.
Metabolic syndrome (MS), a condition characterized by multiple related clinical disorders including insulin resistance, central obesity, hyperlipidemia, hypertension, and heart disease, is an increasingly prevalent disease in industrialized societies. The intense research interest in the peroxisome proliferator-activated receptors (PPARs), by both the pharmaceutical industry and academia, stems...
متن کاملStatin islands and PPAR ligands in platelets.
Platelets are formed from megakaryocytes, where they are released into the blood stream via proplatelet extensions into the blood vessel lumen.1 Being the most numerous “white blood cell” and despite lacking a nucleus, they are highly complex cells containing a surface connected canalicular and tubular system, mitochondria, granules, and bioactive mediators. Platelets are well-known for their s...
متن کاملThe toxicology of ligands for peroxisome proliferator-activated receptors (PPAR).
Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors that modulate target gene expression in response to endogenous and exogenous ligands. Ligands for the PPARs have been widely developed for the treatment of various diseases including dyslipidemias and diabetes. While targeting selective receptor activation is an established therapeutic approach for th...
متن کاملCancer Chemoprevention
1Biology Department, College of Science, UAE University, Al-Ain 17551, UAE 2Zoology Department, Faculty of Science, Cairo University, Cairo 12613, Egypt 3Department for Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 111, Ljubljana, Slovenia 4Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 5Experimental Tum...
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ژورنال
عنوان ژورنال: PPAR Research
سال: 2008
ISSN: 1687-4757,1687-4765
DOI: 10.1155/2008/548919